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References for arthritis pages
Siemoneit U, Pergola C, Jazzar B, et al. On the interference of boswellic acids with 5-lipoxygenase: Mechanistic studies in vitro and pharmacological relevance. Eur J Pharmacol. 2009; 606:246–54.
Singh GB, Atal CK. Pharmacology of an extract of Boswellia serrata. Indian J Pharmacol. 1984; 16:51.
Sharma ML, Bani S, Singh GB. Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. Int Immunopharmacol. 1989; 11:647–52.
Siddiqui MZ Boswellia Serrata, A Potential Anti-inflammatory Agent: An Overview. 2011 Indian J Pharm Sci; 73(3):255-61
Sengupta K, et al Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract . Mol Cell Biochem. (2011)
Takada Y, et al Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression . J Immunol. (2006)
Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KVS et al. A double- blind, randomised, placebo-controlled study of the efficacy and safety of 5-LOXIN® for treatment of osteoarthritis of the knee. Arthritis Research & Therapy 2008; 10(4): 85-9.
Kulkarni R, Patki P, Jog V, Gandage S, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: A double blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991;33:91–5.
Chopra A, Lavin P, Patwardhan B et al. Randomized double blind trial of an Ayurvedic plant derived formulation for treatment of rheumatoid arthritis. J Rheumatol. 2000;27:1365–72.
Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – a randomised, double blind, placebo-controlled trial. Phytomedicine 2003;10(1):3–7
Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L. Open, randomised, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian Journal of Pharmacology 2007; 39:27–29.
Sengupta K, Krishnaraju AV, Vishal AA et al. Comparative efficacy and tolerability of 5-LOXIN® and Aflapin® against osteoarthritis of the knee: a double-blind, randomised, placebo-controlled clinical study. International Journal of Medical Sciences 2010; 7(6):366–77.
Chrubasik JE, Roufogalis BD, Chrubasik S. Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain . Phytother Res. (2007).
Altman RD, Aven A, Holmburg CE, Pfeifer LM, Sack M, Young GT. Capsaicin cream 0.025% as monotherapy for osteoarthritis: a double-blind study. Seminars in Arthritis & Rheumatology 1994; 23 (Suppl):25–33.
McCleane G. The analgesic efficacy of topical capsaicin is enhanced by glyceryl trinitrate in painful osteoarthritis: a randomised, double-blind, placebo-controlled study. European Journal of Pain 2000; 4(4):355–60.
Kosuwon W, Sirichatiwapee W, Wisanuyotin T, Jeeravipoolvarn P, Laupattarakasem W. Efficacy of symptomatic control of knee osteoarthritis with 0.0125% of capsaicin versus placebo. Journal of the Medical Association of Thailand 2010; 93(10): 1188–95.
Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ. Systematic review of topical capsaicin for the treatment of chronic pain. British Medical Journal 2004; 328(7446):991.
Kwan W, Jackson J, Weir L et al Chronic Arm Morbidity After Curative Breast Cancer Treatment: Prevalence and Impact on Quality of Life J Clin Oncol 20:4242-4248. 2002
Pegram M 2001. Docitaxol ond Herceptin: Further strategies. The Oncologist vol 6, sup 3 pp 22-27.
Irwin ML, Cartmel B, Gross C, et al: Randomized trial of exercise vs usual care on aromatase inhibitor-associated arthralgia in women with breast cancer. 2015 JCO 33 (10); 1103-1111
Irwin ML, Varma K, Alvarez-Reeves M, et al.; RCT of aerobic exercise on insulin and IGF in breast cancer survivors: The Yale Survivorship study. Cancer Epidemiol Biomarkers Prev 2009; 18(1): 306-13.
Irwin ML, Alvarez-Reeves M, Cadmus L, Exercise improves body fat, lean mass, and bone mass in breast cancer survivors. Obesity. 2009 17(8):1534-41. doi: 10.1038/oby.2009.18. Epub 2009
Irwin ML, Wilder Smith A, McTiernan A et al.; Influence of Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study. J Clin Oncol 2008; 26(24): 3958-3964.
Davies C, Pan H, Godwin A, et. al. for the Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) Collaborative Group. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. Mar 9, 2013; 381(9869): 805–816.
Hershman DL, Unger JM, Crew KD et al Randomized Multicenter Placebo-Controlled Trial of Omega-3 Fatty Acids for the Control of Aromatase Inhibitor–Induced Musculoskeletal Pain: SWOG S0927 JCO 2015 vol. 33 no. 17 1910-1917.
Thomas R, Oakes R, Gordon J, et al: A randomised, double-blind phase II study of lifestyle counselling and salicylate compounds in patients with progressive prostate cancer. Nutrition & Food Science, 39(3):295-305, 2009
Thomas KJ, Coleman P et al. Use of complementary or alternative medicine in a general population in Great Britain. Results from the National Omnibus Survey. Journal of Public Health 2004; 26:152–57.
Thomas KJ, Nicholl JP, Coleman P. Use and expenditure on complementary medicine in England: a population based survey. Complementary Therapies in Medicine 2001; 9:2–11.
Thomas R, C Marshall, M Williams, L Walker Can switching to Aromatase inhibitors in tamoxifen intolerant post menopausal women improve hot flushes, toxicity, qol and mood? British Journal of Cancer (2008) 98, 1494-1499.
Thomas R, Daly M, Perryman B, Stockton D. Forewarned is forearmed – benefits of preparatory information on video cassette for patients receiving chemotherapy or radiotherapy – a randomised controlled trial. Eur J Cancer. 2000;36:1536-1543.
Thomas R, Thornton H, Mackey J. Patient information materials in oncology: are they needed and do they work? Clin Oncol (R Coll Radiol). 1999; 11:225-231.
A double blind, placebo controlled randomised trial (RCT) evaluating the effect of a polyphenol rich whole food supplement on PSA progression in men with prostate cancer – The UK National Cancer Research Network (NCRN) Pomi-T study. R Thomas, M Williams1, H Sharma, A Chaudry, P Bellamy. Prostate Cancer and Prostatic Diseases March 2014 17, pp180-6 (doi:10.1038/pcan.2014.6)
The benefits of exercise after cancer – An international review of the clinical and microbiological benefits. (2014) R Thomas & M Holmes. The British Journal of Medical Practitioners, vol 7 number 1, pp2-9.
Phytochemicals in cancer prevention and management ? Robert Thomas, Elizabeth Butler, Fabio Macchi and Madeleine Williams BJMP June 2015 Volume 8 Number 2
Chlebowski R, Aiello E, McTiernan A; Weight loss in breast cancer patient management. J Clin Oncol 2002; 20(4): 1128-1143
Kenfield SA, Stampfer MJ, Giovannucci E, et al.; Physical Activity and Survival After Prostate Cancer Diagnosis in the Health Professionals Follow-Up Study. J Clin Oncol 2011; 29(6): 726-732.
Richman EL, Kenfield SA, Stampfer MJ, et al. Physical Activity after Diagnosis and Risk of Prostate Cancer Progression: Data from the Cancer of the Prostate Strategic Urologic Research Endeavor. Cancer Res 2011; 71(11): 1-7.
Pierce JP, Natarajan, Caan BJ,et al. Influence of fibre, vegetables and exercise after breast cancer. 2007 JAMA 18, 298 (3) 289-98.
Sternfeld B et al Life after cancer epidemiology LACE study. 2005 Cancer Causes Control 16(50 545-56
Fong DY, Ho JW, Hui BP, Lee AM, Macfarlane DJ, Leung SS. Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ 2012 Jan;344e70
Schmitz KH, Courneya KS, Matthews C et al. (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exercise 42: 1409-26
Markes M, Brockow T, Resch K (2006): Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database of systemic reviews: art no.CD005001. Doi 10.1002/14651858.CD005001.pub2.;
McNeeley M, Campbell K, Rowe B et al (2006) Effects of exercise on breast cancer patients and survivors: A systemic review and meta-analysis. Canadian Medical Association Journal 175:34-41.
Haydon AM, McInnis RJ, English DR, et al.; The effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut 2006; 55(1): 62-67.
Reddy KS, Roy A Cardiovascular risk of NSAIDs: time to translate knowledge into practice. PLoS Med. 2013; 10(2):e1001389. Epub 2013.
Haslock I, Monro R, Nagarathna R, Nagendra HR, Raghuram NV. Measuring the effects of yoga in rheumatoid arthritis. Br J Rheumatol 1994; 33(8):787-788.
Felson DT. Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther. 2009;11:203. doi: 10.1186/ar2531.
Felson DT, Chaisson CE: Understanding the relationship between body weight and osteoarthritis. Baillieres Clinical Rheumatology 1997;11:671-681.
Felson DT, Zhang Y, Hannan MT, et al: Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum. 1997;40:728-
Bao T, Cai L, Giles JT, et al. A dual-center randomized controlled double blind trial assessing the effect of acupuncture in reducing musculoskeletal symptoms in breast cancer patients taking aromatase inhibitors. Breast Cancer Res Treat. 2013;138(1):167–174.
Schouten JS, van den Ouweland FA, Valkenburg HA: A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee. Ann Rheum Dis. 1992;51:932-937.
Wang Y, Hodge A, Wluka A, English D, Giles G, O’Sullivan R, et al. Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study. Arthritis Res Ther 2007; 9:R66.
McAlindon TE, Jacques P, Zhang Y, Hannan MT, Aliabadi P, Weissman B, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum 1996; 39:648–56.
Williams FM, Skinner J, Spector TD, Cassidy A, Clark IM, Davidson RM, et al. Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action. BMC Musculoskelet Disord 2010;11:280.
Hanninen J, Kaartinen K, Rauma AL, Nenonen M, Torronen R, Hakkinen AS, Adlercreutz H, Laakso J. Antioxidants in vegan diet and rheumatic disorders. Toxicology. 2000;155(1-3):45-53.
Muller H, de Toledo FW, Resch KL. Fasting followed by vegetarian diet in patients with rheumatoid arthritis: a systematic review. Scand J Rheumatol. 2001;30(1):1-10
Kjeldsen-Kragh J, Borchgrevink CF, Laerum E, et al Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis The Lancet, Volume 338, Issue 8772, Pages 899 – 902
Shen CL, Smith BJ, Lo DF Dietary polyphenols and mechanisms of osteoarthritis. J Nutr Biochem. 2012 Nov;23(11):1367-77. doi: 10.1016/j.jnutbio.2012.04.001. Epub 2012 Jul 23.
Bishop FL, Yardley L, Lewith GT. A systematic review of beliefs involved in the use of complementary and alternative medicine. Journal of Health Psychology 2007; 12:851–67.
Kikuchi M, Matsuura K, Matsumoto Y, Inagaki T, Ueda R. Bibliographical investigation of complementary alternative medicines for osteoarthritis and rheumatoid arthritis. Geriatr Gerontol Int. 2009;9:29–40. doi: 10.1111/j.1447-0594.2008.00503.x.
Penfei Hu, Weping C, Jiapeng B, et al Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study Int J Clin Exp Pathol. 2014; 7(10): 6575–6584.
Won SY, Park EH. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol. 2005;96:555–61. [PubMed]
Kim HG, Shrestha B, Lim SY, Yoon DH, Chang WC, Shin DJ, Han SK, Park SM, Park JH, Park HI, Sung JM, Jang Y, Chung N, Hwang KC, Kim TW. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006;545:192–9. [PubMed]
Yoo HS, Shin JW, Cho JH, Son CG, Lee YW, Park SY, Cho CK. Effects of Cordyceps militaris extract on angiogenesis and tumor growth. Acta Pharmacol Sin. 2004;25:657–65. [PubMed]
Lee YR, Noh EM, Jeong EY, Yun SK, Jeong YJ, Kim JH, Kwon KB, Kim BS, Lee SH, Park CS, Kim JS. Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappaB pathway in human dermal fibroblasts. Exp Mol Med. 2009;41:548–54. [PMC free article] [PubMed]
Lee SJ, Kim SK, Choi WS, Kim WJ, Moon SK. Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. Arch Biochem Biophys. 2009;490:103–9. [PubMed]
Rao YK, Fang SH, Tzeng YM. Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts. J Ethnopharmacol. 2007;114:78–85. [PubMed]
Noh EM, Kim JS, Hur H, Park BH, Song EK, Han MK, Kwon KB, Yoo WH, Shim IK, Lee SJ, Youn HJ, Lee YR. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford) 2009;48:45–8. [PubMed]
Yan WJ, Li TH, Lin QY, Song B, Jiang ZD Safety assessment of Cordyceps guangdongensis. Food Chem Toxicol 2010; 48 (11): 3080-4.
Yoo HS, Lee HJ, Kim JS, Yoon J, Lee GH et al A toxicological study of HangAmDan-B (Cordyceps) in mice.J Acupunct Meridian Stud. 2011; 4(1): 54-60
Fox BA, Stephens MM. Glucosamine/chondroitin/primorine combination therapy for osteoarthritis. Drugs Today (Barc) 2009;45:21–31. doi: 10.1358/dot.2009.45.1.1314053.
TowheedT,MaxwellL,AnastassiadesTP,SheaB,HouptJ,RobinsonVetal. Glucosamine therapy for treating osteoarthritis. Cochrane Database Systematic Review 2005; 18(2):CD002946.
Arthritis Research UK [Registered Charity No 207711] © 2012 Published October 2012 3300/CAM-REP/12-1. ISBN 978-1-901815-13-9
Bruyere O, Pavelka K, Rovati L et al Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopuase 2004; 11(2):138-43.
Wandel S, Juni P, Tendal B Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysismeta-analysis. BMJ 2010; 341.
Deliorma O,, Harteviogui A, Kupeli E, Yesilada E. In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits. J Ethnopharmacol 2007;112:394–400. Search PubMed
Lattanzio F, Greco E, Carretta D, Cervellati R, Govoni P, Speroni E. In vivo anti-inflammatory effect of Rosa canina L. extract. J Ethnopharmacol 2011;137:880–5. Search PubMed
Schwager J, Hoeller U, Wolfram S, Richard N. Rosehip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement Altern Med 2011;11:105. Search PubMed
Larsen E, Kharazmi A, Christensen LP, Christensen SB. An antiinflammatory galactolipid from rosehip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J Nat Prod 2003;66:994–5. Search PubMed
Winther K, Rein E, Kharazmi A. The antiinflammatory properties of rose-hip. Inflammopharmacology 1999;7:63–8. Search PubMed
Winther K. Rose-hip in the form of HybenVital, has no impact on coagulation, platelet function and fibrinoloysis in Third International Exhibition and Conference on Nutraceuticals and Food for Vitality. 2000: Palexpo Exhibition and Conference Centre, Geneva, Switzerland.
Rossnage lK, Roll S, Willich SN. The clinical effectiveness of rosehip powder in participants with osteoarthritis. A systematic review. MMW – Fortschritte der Medizin 2007; 149(11):51–56.
Chrubasik C, Duke RK, Chrubasik S. The evidence for clinical efficacy of rosehip and seed: a systematic review. Phytotherapy Research 2006; 20(1):1–3.
ReinE, Kharazmi A, WintherK.Aherbalremedy,HybenVital(stand.powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in participants with osteoarthritis – a double-blind, placebo-controlled, randomised trial. Phytomedicine 2004; 11(5):383–91.
Warholm O, SkaarS,HedmanE,MolmenHM,EikL.Theeffectsofastandardized herbal remedy made from a subtype of Rosa canina in participants with osteoarthritis: a double-blind, randomised, placebo-controlled clinical trial. Current Therapeutic Research 2003; 64:21–31.
WillichSN,RossangelK,RollS,WagnerA,MuneO,ErlendsonJ,KharazmiA, Sörensen H, Winther K. Rose hip herbal remedy in participants with rheumatoid arthritis – a randomised controlled trial. Phytomedicine 2010; 17:87–93.
Winther K, Apel K, Thamsborg G. A powder made from seeds and shells of a rose- hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomised, double-blind, placebo-controlled clinical trial. Scandinavian Journal of Rheumatology 2005; 34(4):302–08.
Lattanzio F, Greco E, Carretta D, Cervellati R, Govoni P, Speroni E. In vivo anti-inflammatory effect of Rosa canina L. extract. J Ethnopharmacol 2011;137:880–5. Search PubMed
Schwager J, Hoeller U, Wolfram S, Richard N. Rosehip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement Altern Med 2011;11:105. Search PubMed
Larsen E, Kharazmi A, Christensen LP, Christensen SB. An antiinflammatory galactolipid from rosehip (Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro. J Nat Prod 2003;66:994–5. Search PubMed
Winther K, Rein E, Kharazmi A. The antiinflammatory properties of rose-hip. Inflammopharmacology 1999;7:63–8. Search PubMed
Winther K. Rose-hip in the form of HybenVital, has no impact on coagulation, platelet function and fibrinoloysis in Third International Exhibition and Conference on Nutraceuticals and Food for Vitality. 2000: Palexpo Exhibition and Conference Centre, Geneva, Switzerland.
ClelandLG,CaugheyGE,JamesMJ,ProudmanSM.Reductionofcardiovascularrisk factors with long-term fish oil treatment in early rheumatoid arthritis. Journal of Rheumatology 2006; 33(10):1973–79.
FortinPR,LewRA,LiangMH.Validationofameta-analysis:theeffectsoffishoil in rheumatoid arthritis. Journal of Clinical Epidemiology 1995; 48(11):1379–90.
Giovannucci E, Rimm EB, Liu Y, et al: A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 94:391-398, 2002
Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR. Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1) Arthritis Rheum. 2000;43:673–682. doi: 10.1002/1529-0131(200003)43:3<673::AID-ANR25>3.0.CO;2-8.
Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, Geoghegan KF, Hambor JE. Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. J Clin Invest. 1996;97:761–768. doi: 10.1172/JCI118475.
Brinckerhoff CE, Matrisian LM. Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol. 2002;3:207–214. doi: 10.1038/nrm763.
Jurenka JS. Anti-inflammatory properties of curcumin, major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun;14(2):141-53. Review. Erratum in: Altern Med Rev. 2009 Sep;14(3):277.
Jurenka JS. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008 Jun;13(2):128-44.
White B, Judkins DZ. Clinical Inquiry. Does turmeric relieve inflammatory conditions? J Fam Pract. 2011 Mar;60(3):155-6.
Lao CD, Ruffin MT 4th, Normolle D. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006 Mar 17;6:10.
Sharma RA, Steward WP, Gescher AJ. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol. 2007;595:453-70.
Shah BH, et al (1999). Inhibitory effect of curcumin, on platelet-activating factor through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol., 58(7): 1167–1172.
Funk JL1, Frye JB, Oyarzo JN et al Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis 2006. Arthritis Rheum. 54(11):3452-64.
Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo controlled, cross-over study. J Ethnopharmacol 1991;33:91-95.
Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J. 2013 Nov 25; 12(1):154. Epub 2013 Nov 25.
KuptniratsaikulV,ThanakhumtornS,ChinswangwatanakulP,Wattanamongkonsil L, Thamlikitkul V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. Journal of Alternative and Complementary Medicine 2009; 15(8):891–97.
Belcaro G, Cesarone MR, Dugall M et al. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 2010;52:55-62.
Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998;64:353-356.
Manning J, Roberts JC. Analysis of catechin content of commercial green tea products. J Herb Pharmacother. 2003;3:19–32. doi: 10.1300/J157v03n03_03.
Cooper R, Morre DJ, Morre DM. Medicinal benefits of green tea: part I. Review of noncancer health benefits. J Altern Complement Med. 2005;11:521–528. doi: 0.1089/acm.2005.11.521
Doss MX, Potta SP, Hescheler J, Sachinidis A. Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases. J Nutr Biochem. 2005;16:259–266. doi: 10.1016/j.jnutbio.2004.11.003.
Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three tissues. Bull NYU Hosp Jt Dis. 2008;66:244–250.
Malemud CJ, Islam N, Haqqi TM. Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs. 2003;174:34–48. doi:
Singh R, Ahmed S, Malemud CJ, Goldberg VM, Haqqi TM. Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes. J Orthop Res. 2003;21:102–109. doi: 10.1016/S0736-0266(02)00089-X.
Ahmed S, Wang N, Hafeez BB, et al. Punica granatum L. extracts inhibits IL-1Beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro. J Nutr 2005;135:2096-2102.
Ahmed S, Wang N, Lalonde M, Goldberg VM, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. J Pharmacol Exp Ther. 2004;308:767–773. doi: 10.1124/jpet.103.059220.
Ahmed S, Rahman A, Hasnain A, Lalonde M, Goldberg VM, Haqqi TM. Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med. 2002;33:1097–1105. doi: 10.1016/S0891-5849(02)01004-3.
Ahmed S, Pakozdi A, Koch AE. Regulation of interleukin-1β-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2006;54:2393–2401. doi: 10.1002/art.22023.
Adcocks C, Collin P, Buttle DJ. Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro. J Nutr. 2002;132:341–346.
Vankemmelbeke MN, Jones GC, Fowles C, Ilic MZ, Handley CJ, Day AJ, Knight CG, Mort JS, Buttle DJ. Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters. Eur J Biochem. 2003;270:2394–2403. doi: 10.1046/j.1432-1033.2003.03607.x.
Goo HC, Hwang YS, Choi YR, Cho HN, Suh H. Development of collagenase-resistant collagen and its interaction with adult human dermal fibroblasts. Biomaterials. 2003;24:5099–5113. doi: 10.1016/S0142-9612(03)00431-9.
Haqqi TM, Anthony DD, Gupta S, Ahmad N, Lee MS, Kumar GK, Mukhtar H. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci USA. 1999;96:4524–4529. doi: 10.1073/pnas.96.8.4524.
Salahuddin Ahmed Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise Arthritis Res Ther. 2010; 12(2): 208. 2010. doi: 10.1186/ar2982
Taylor JR and Wilt VM. Probable antagonism of warfarin by green tea. Ann Pharmacother. 1999 Apr;33(4):426-8.
Heck AM, DeWitt BA and Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7; quiz 1228-30.
Ignarro LJ, Byrns RE, Sumi D, et al. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide 2006;15:93-102.
Lansky EP, Jiang W, Mo H, et al. Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. Invest New Drugs 2005;23:11-20.
Lansky EP, Harrison G, Froom P, Jiang WG. Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion. Invest New Drugs 2005;23:121-122.
Schubert SY, Lansky EP, Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol 1999;66:11-17.
Balbir-Gurman A, Fuhrman B, Braun-Moscovici Y, Markovits D, Aviram M. Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis: a pilot study. Isr Med Assoc J. 2011 Aug;13(8):474-9.
Juge N, Mithen RF, Traka M. Molecular basis for chemopreven- tion by sulforaphane: a comprehensive review. Cell Mol Life Sci 2007;64:1105–27.
Dinkova-Kostova AT, Kostov RV. Glucosinolates and isothiocyanates in health and disease. Trends Mol Med 2012;18:337–47.
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, et al. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterio- scler Thromb Vasc Biol 2009;29:1851–7.
Brandenburg LO, Kipp M, Lucius R, Pufe T, Wruck CJ. Sulforaphane suppresses LPS-induced inflammation in primary rat microglia. Inflamm Res 2010;59:443–50.
Megias J, Guillen MI, Clerigues V, Rojo AI, Cuadrado A, Castejon MA, et al. Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglan- din E2 production in osteoarthritic chondrocytes. Biochem Phar- macol 2009;77:1806–13.
Kim HA, Yeo Y, Jung HA, Jung YO, Park SJ, Kim SJ. Phase 2 enzyme inducer sulphoraphane blocks prostaglandin and nitric oxide synthesis in human articular chondrocytes and inhibits cartilage matrix degradation. Rheumatology 2012;51:1006–16.
Kong JS, Yoo SA, Kim HS, Kim HA, Yea K, Ryu SH, et al. Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate. Arthritis Rheum 2010;62:159–70.
Young D, Lakey R, Pennington C, Jones D, Kevorkian L, Edwards D, et al. Histone deacetylase inhibitors modulate metalloprotei- nase gene expression in chondrocytes and block cartilage resorp- tion. Arthritis Res Ther 2005;7:R503–12.
Culley KL, Hui W, Barter MJ, Davidson RK, Swingler TE, Destrument AP, et al. Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine induced cartilage degradation. Arthritis Rheum 2013;65:1822–30.
Davidson R, Jupp O, De Ferrars R et al Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo’ by is published in Arthritis & Rheumatism Arthritis & Rheumatism 65 (12), pp 3130–40
Moore LE, Brennan P, Karami S, et al. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis. 2007 Sep;28(9):1960-4. Epub 2007 Jul 7. 2007.
Cornelis MC, El-Sohemy A, Campos H. GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. Am J Clin Nutr. 2007 Sep;86(3):752-8. 2007.
Traka M, Mithen R 2009. Glucosinolates, isothiocyanates and human health. Phytochemistry Reviews 8: 269-282.
Fenwick GR and Heaney RK. Glucosinolates and their breakdown products in cruciferous crops, foods and feeding stuffs. Food Chem 11:249-271
McMillan M, Spinks EA, and Fenwick GR. Preliminary observations on the effect of dietary brussels sprouts on thyroid function. Hum Toxicol. 1986;5(1):15-19. 1986.
Reichenbach et al Anns of Int Med 2007; 146(8):580
Deliorman Orhan D, Harteviogui A, Kupeli E, Yesilada E. In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits. J Ethnopharmacol 2007;112:394–400. Search PubMed
Baker R.G.; Hayden, M.S.; Ghosh, S. NF-κB, inflammation, and Metabolic Disease. Cell Metab. 2001, 13, 11–22.
Bailey, S.J.; Winyard, P.; Vanhatalo, A. et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J. Appl. Physiol. 2009, 107, 1144–1155.
Bondonno, C.P.; Downey, L.A.; Croft, K.D. et al. The acute effect of flavonoid-rich apples and nitrate-rich spinach on cognitive performance and mood in healthy men and women. Food Funct. 2014, 5, 849–858.
Cermak, N.M.; Gibala, M.J.; van Loon, L.J.C. Nitrate supplementation’s improvement of 10-km time-trial performance in trained cyclists. Int. J. Sports Nutr. Exerc. 2012. 22, 64–71.
Clifford T, Howatson G, Daniel J. West D et al. The Potential Benefits of Red Beetroot Supplementation in Health and Disease Nutrients 2015, 7, 2801-2822.
Das, S.; Williams, D.S.; Das, A.; Kukreja, R.C. Beet root juice promotes apoptosis in oncogenic MDA-MB-231 cells while protecting cardiomyocytes under doxorubicin treatment. J. Exp. Second. Sci. 2013, 2, 1–6.
Hobbs, D.A.; George, T.W.; Lovegrove, J.A. The effects of dietary nitrate on blood pressure and endothelial function: A review of human intervention studies. Nutr. Res. Rev. 2013, 26, 210–222.
Kapadia, G.J.; Azuine, M.A.; Rao, G.S.; Arai, T.; Iida, A.; Tokuda, H. Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. Anti -Cancer Agent Med. Chem. 2011, 11, 280–284.
Kapadia, G.J.; Azuine, M.A.; Sridhar, R.; Okuda, Y.; Tsuruta, A.; Ichiishi, E.; Mukainakec, T.; Takasakid, M.; Konoshimad, T.; Nishinoc, H.; et al. Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot. Pharmacol. Res. 2003, 47, 141–148.
Kim-Shapiro, D.B.; Gladwin, M.T. Mechanisms of nitrite bioactivation. Nitric Oxide 2014, 38, 58–68.
Lansley, K.E.; Winyard, P.G.; Bailey, S.J.; Vanhatalo, A.; Wilkerson, D.P.; Blackwell, J.R.; Gilchrist, M.; Benjamin, N.; Jones, A.M. Acute dietary nitrate supplementation improves cycling time trial performance. Med. Sci. Sports Exerc. 2011, 43, 1125–1131.
Lechner, J.F.; Wang, L.S.; Rocha, C.M. et alDrinking water with red beetroot food color antagonizes esophageal carcinogenesis in N-nitrosomethylbenzylamine-treated rats. J. Med. Food 2010, 13, 733–739.
Lundberg, J.O.; Weitzberg, E.; Gladwin, M.T. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat. Rev. 2008, 7, 156–167.
Ninfali, P.; Angelino, D. Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia 2013, 89, 188–199.
Ormsbee, M.J.; Lox, J.; Arciero, P.J. Beetroot juice and exercise performance. J. Int. Soc. Sports Nutr. 2013, 5, 27–35.
Pietrzkowski, Z.; Nemzer, B.; Spórna, A.; Stalica, P.; Tresher, W.; Keller, R.; Jiminez, R.; Michalowski, T.; Wybraniec, S. Influence of betalin-rich extracts on reduction of discomfort associated with osteoarthritis. New. Med. 2010, 1, 12–17.
Presley, T.D.; Morgan, A.R.; Bechtold, E. et al. Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide 2011, 24, 34–42.
Raphaeolle L, Santarelli RL, Pierre F, Corpet DE Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence Nutr Cancer. 2008; 60(2): 131–144.
Reddy, M.K.; Alexander-Lindo, R.L.; Nair, M.G. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J. Agric. Food Chem. 2005, 53, 9268–9273.
Tannenbaum SR, Wishnok JS, Leaf CD. “Inhibition of nitrosamine formation by ascorbic acid”. The American Journal of Clinical Nutrition. 1991, 53 247–250.
Vanhatalo, A.; Bailey, S.J.; Blackwell, J.R.; et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am. J. Physiol. -Reg. I 2010, 299, 1121–1131.
Vidal, P.J.; López-Nicolás, J.M.; Gandía-Herrero, F.; García-Carmona, F. Inactivation of lipoxygenase and cyclooxygenase by natural betalains and semi-synthetic analogues. Food. Chem. 2014, 154, 246–254.
Vulić, J.J.; Ćebović, T.N.; Čanadanović-Brunet, J.M.; Ćetković, G.S.; Čanadanović, V.M.; Djilas, S.M.; Tumbas Šaponjac, V.T. In vivo and in vitro antioxidant effects of beetroot pomace extracts. J. Funct. Foods 2014, 6, 168–175.
Wootton-Beard, P.C.; Brandt, K.; Fell, D.; Warner, S.; Ryan, L. Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteers. J. Nutr. Sci. 2011, 3, 1–9.